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Another trial, SOUL (NCT03914326), has now been initiated to overcome the shortcomings of PIONEER 6 with a primary endpoint focused at proving CV superiority vs placebo

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The HbA1c reductions rival dedicated diabetes medications, and improved insulin sensitivity accompanies weight loss

Table of Contents Understanding Metformin and Semaglutide in Diabetes and Obesity How Metformin and Semaglutide Work Together Clinical Evidence for Combined Treatment Dosing, Administration and Treatment Guidelines Side Effects and Safety Considerations NHS Prescribing and Patient Eligibility Criteria Frequently Asked Questions Understanding Metformin and Semaglutide in Diabetes and Obesity Type 2 diabetes and obesity represent two interconnected chronic conditions that affect millions of people across the UK